Topley’s Top 10 – April 10, 2023

1. S&P 500 performance around the end of Fed hiking cycles – GS

Internet Bubble was only negative returns since the 1980s after Fed ends rate hike cycle

2. Q1 ETF Leaders All Technology

3. Micro-Cap Stocks Make New Lows as Large Cap Dominates Q1

4. IPO Market Chart to Watch

IPO ETF look for break above this red downtrend line on chart



5. 20-Year Treasury Bond 4th Run at New High

6. Just a Reminder that 10-Year Treasury Yield Broke Downtrend Line Going Back to 1981

7. U.S. Federal Government Spending vs. Inflation

@Charlie Bilello A look at federal government spending tells the story, with a 185% increase over the last 20 years, far greater than the overall rate of inflation (64%).

8. Lumber $360 Would Be New Lows….$1700 in May 2021

9. Billionaires Pouring Money into Fountain of Youth

EXCLUSIVE: First anti-aging pills to hit shelves in 2028, expert predicts – as Silicone Valley races to conquer death

Pills that can help a person reverse the effects of aging could be on the market in the next five years, according to an expert.

Sam Altman, 37, was revealed to have funded biotech startup Retro BioScience to the tune of $180million last month. He is the latest in a long line of Silicon Valley billionaires to throw their considerable wealth behind the science of aging.

Amazon’s Jeff Bezos is reported to have invested $3billion in life-extension startup Altos Labs. PayPal co-founder Peter Thiel invested in the Methuselah Foundation, which has the goal of making ’90 the new 50′.


Steele said: ‘With these billionaires, I’m sure some of them are doing it purely for personal gain — they’ve got all this money and they can’t possibly spend it in a single human lifetime.

‘But… if you’re a savvy investor, you can see that anti-aging medication is a huge business opportunity because the potential market is every living human.

‘I think it’s going to be the biggest revolution in medicine since the discovery of antibiotics — and as a savvy business person, you want to be on the leading edge of that revolution.’

While aging does not directly kill people, older people are at risk of many deadly diseases such as Alzheimer’s, heart disease and cancer.

Researchers might have found a way to teach someone’s body to refresh their old blood

Around 100,000 people die from age-related diseases every day, according to the World Health Organization.

Mr Steele says: ‘Aging is the greatest humanitarian challenge of all time.

There are ’20 to 30’ companies developing new drugs known as ‘senolytics’ which kill aging cells in the body, he explained.

In mice, these drugs cause elderly animals to become lively and healthy suddenly.

‘Many of these drugs are drugs that we already understand and use for different purposes, so we don’t have to develop new medications,’ Mr Steele said.

An example of a senolytic treatment is the combination of datasinib, used for chemotherapy, and quercetin, a molecule found in fruits and vegetables.

Used together, they remove aged ‘senescent’ cells responsible for many of the problems associated with aging.

Another potential general anti-aging drug is metformin. First approved in 1994 for type 2 diabetes, the drug has shown promise extending lifespans by improving blood vessel health.

‘Some of those companies are trying to develop new and more effective drugs that could do the same thing better,’ the author said.

‘That’s the sort of thing that’s very, very close to clinical realization. And I’d be shocked if in five years we don’t have some senolytics in the clinic.

‘It probably won’t be for aging at first. It’ll be for a specific disease – and maybe in 10 years, we’ll use it for aging.

‘These things are very, very near term.’

Jeff Bezos’s investment in Altos Labs — the biggest biotechnology company launch of all time — is a longer shot, Steele believes.

The firm specializes finding and developing cell therapies that can halt and eventually reverse the process of aging.

Mr Steele says: ‘This relies on a process called cellular reprogramming. It’s been shown to work on cells in a dish, and there’s some evidence it works in mice – but it’s an incredibly complicated piece of science.

‘It’s like science that seems to have fallen through a wormhole from the future – and even if it does work, do we have the biological applied understanding in the 2020s to turn that into a workable treatment?’

When Altos Labs was announced, Elon Musk quipped on Twitter about the Amazon mogul: ‘If it doesn’t work, he’s gonna sue death!’


With labs launching in America and Cambridge, the company is reputed to pay scientists poached from the world’s top universities salaries of up to a million dollars a year.

Steele says that, realistically, treatments we are likely to see in the near term will extend ‘healthspan’ by dealing with age-related diseases — delaying the onset of problems such as dementia.

Dr Cathy Slack, a biologist from the University of Aston, in the UK, agrees, telling ‘The goal is to increase the number of years of healthy lifespan rather than extending the late-life period of poor health.’

She said there are now ‘many’ published studies that show that genetic or environmental changes can extend a healthy lifespan.

She says: ‘Many of the biological systems that have been shown to play a role in healthy aging in these animal models are also present in humans and perform similar functions – so there is every reason to believe that these same processes are impacting on human aging.

‘The ultimate goal is really to try and manipulate these systems during human aging to maintain health and quality of life.’

Dr Slack believes that successful treatments are likely to be a combination of drugs and lifestyle changes – and look holistically at all the diseases that afflict people in later life.

She says: ‘Historically, we have viewed the various diseases associated with older age as distinct entities – so research tends to focus on each one rather than looking at them more holistically together as a direct consequence of biological aging.

‘We already know that there are lifestyle changes that will help to maintain multiple aspects of heath during aging.

‘Exercise, for example. But supplementation with drugs that target multiple physiological parameters of aging could have a huge impact on quality of life for older adults.’

10. The Daily Stoic Are You Showing Them How To Be A Student?

“Live as if you were to die tomorrow. Learn as if you were to live forever.”

—Mahatma Gandhi

If you think back to when you were a kid, what appeared to you to be the best part about being an adult? No more school. Our parents didn’t have to carry around heavy books or do homework. We never saw them applying to get into this school or that one. It’s sort of sad that, by and large, we show our kids that education stops. That while adulthood is isn’t always fun, one perk is that you no longer have to go to class. That graduation is a final destination.

It doesn’t have to be this way. There’s the story of Epictetus teaching one day when a student’s arrival caused a commotion in the back of the room. Who was it? Hadrian, the emperor. Hadrian’s example clearly had an impact on his successor and adopted grandson, Marcus Aurelius. Late in his reign, a friend spotted Marcus heading out, carrying a stack of books. “Where are you going?” he asked. Marcus was on his way to a lecture on Stoicism, he said, for “learning is a good thing, even for one who is growing old. I am now on my way to Sextus the philosopher to learn what I do not yet know.

If you want your kids to value learning, if you want them to never stop furthering the education you’ve been investing so much time and money and care and worry into, then we have to show them what an adult committed to lifelong learning actually looks like. We have to show them we have not graduated, we are not on summer break, we have not arrived at the final destination of education.

Wisdom, they must learn, is an endless pursuit.