Category Archives: Daily Top Ten

TOPLEY’S TOP 10 September 05, 2025

1. Second Largest Weekly Inflow into Small Caps Ever

David Marlin


2. Gold to S&P Historical Correlation Shift

The Kobeissi Letter


3. Chineses Internet Stocks KWEB Breaks Above 2022 Levels

StockCharts


4. Chinese Margin Balances Break Above 2014 Levels

ZeroHedge


5. Trump Media DJT -50% for 2025

Trump Media & Technology Group Corp


6. Ethereum Reserves Lowest Level in 3 Years

Zerohedge–Ether (ETH) reserves on centralized exchanges have fallen to the lowest level in three years as demand grows from investment funds and corporate buyers.

According to data from CryptoQuant, reserves have dropped by nearly 10.7 million ETH since peaking at around 28.8 million in September 2022. Holdings now stand at about 17.4 million ETH, with roughly 2.5 million ETH leaving exchanges in the past three months alone.

The shrinking supply comes as new channels for Ether exposure have gained traction. Spot ETH exchange-traded funds (ETFs), launched in July 2024, have since attracted net inflows of more than $13 billion, according to CoinGlass data. Between June and August, the funds pulled in over $10 billion in net inflows, led by a record $5.4 billion in July alone.

Corporate treasuries are also driving demand. Several publicly traded companies have announced ETH treasuries over the past few months, with regular corporate purchases affecting the token’s supply on exchanges.

ZeroHedge

Ethereum exchange reserves – All exchanges. Source: CryptoQuant


7. Bitcoin held by public companies passes 1 million BTC amid asset’s rising popularity

By RT Watson

Quick Take

  • The total amount of bitcoin held by public companies has surpassed 1 million BTC, according to BitcoinTreasuries data.
  • Companies eager to capitalize on Bitcoin’s steady price growth have been accumulating the cryptocurrency.

The total amount of bitcoin held by public companies surpassed 1 million  BTC -1.68% on Thursday, according to BitcoinTreasuries data.Over the past year, the number of companies seeking to capitalize on bitcoin’s steady price growth has been increasing rapidly. Michael Saylor’s Strategy is considered the pioneer of the trend, with many other companies also deciding to hold the cryptocurrency, including Bitcoin miners like Mara Holdings and firms such as Metaplanet, Semler Scientific, and GameStop all holding BTC on their balance sheets. 

https://www.theblock.co/post/369495/bitcoin-held-by-public-companies-passes-1-million-btc-amid-assets-rising-popularity


8. New AI Billionaires

Visual Capitalist


9. CNBC’s Official NFL Team Valuations 2025

Rank Team Value Revenue EBITDA Debt as % of value Owner(s)
1 Dallas Cowboys $12.5B $1.27B $577M 2% Jerry Jones
2 Los Angeles Rams $10.7B $875M $252M 28% Stanley Kroenke
3 New York Giants $10.5B $765M $211M 4% John Mara, Steven Tisch
4 Las Vegas Raiders $9.3B $832M $202M 14% Mark Davis
5 New England Patriots $9.25B $789M $220M 4% Robert Kraft
6 New York Jets $9.1B $730M $199M 6% Woody Johnson, Christopher Johnson
7 Chicago Bears $8.9B $627M $74M 1% The McCaskey family, Ryan family
8 San Francisco 49ers $8.6B $745M $113M 3% The York family
9 Miami Dolphins $8.55B $740M $158M 6% Stephen Ross
10 Philadelphia Eagles $8.5B $735M $124M 2% Jeffrey Lurie

https://www.cnbc.com/2025/09/04/cnbcs-official-nfl-team-valuations-2025.html


10. The Brain Reset Revolution: Why Ibogaine Could Transform Mental Health

Mark Hyman, MD 

Co-Founder & Chief Medical Officer of Function Health

September 3, 2025

We’re living through a mental health crisis of unprecedented scale. The WHO reports that one out of every two people will have a psychiatric diagnosis at some point in their lifetime. Let that sink in: half of humanity will struggle with mental illness.

Our current psychiatric treatments aren’t meeting this challenge.

When you look at the pivotal trials that led to Prozac’s approval, the difference between the active drug and placebo was just 2-3 points on a 60-point scale. The noise between different raters evaluating patients was the same magnitude as the treatment effect. We’re essentially treating people with tools that barely outperform chance.

But there’s a compound that’s changing everything we thought we knew about treating mental illness, and it comes from the bark of an African tree.

The Ibogaine Revolution

I recently interviewed Dr. Nolan Williams from Stanford, whose groundbreaking research on ibogaine is rewriting the rules of psychiatry. This compound, used ceremonially for centuries by the Bwiti people of Gabon, doesn’t work like anything in our current psychiatric arsenal.

The results from Dr. Williams’ study with 30 special operations veterans suffering from traumatic brain injury were staggering:

  • 88% reduction in PTSD symptoms
  • 87% reduction in depression
  • 81% reduction in anxiety
  • Dramatic improvement in cognitive function
  • Disability ratings dropped from moderate to essentially none

When Dr. Williams first saw these results, he didn’t believe them. He made his postdoc reanalyze the data multiple times.

How It Actually Works

Unlike our crude “single key, single lock” approach to psychiatric medication, ibogaine acts on virtually every neurotransmitter system in the brain simultaneously. It’s what we call a “pleiotropic” compound, one that works through multiple pathways.

The mechanism is revolutionary:

  • Dopamine System Reset: Ibogaine upregulates glial-derived neurotrophic factor (GDNF), which restores dopamine neuron health. In animal studies, mice trained to self-administer alcohol until death would completely stop after a single ibogaine dose.
  • Brain Plasticity Enhancement: It increases brain-derived neurotrophic factor (BDNF), promoting neurogenesis and neuroplasticity, literally growing new brain cells and connections.
  • Life Review Process: Unlike MDMA, which requires guided therapy, ibogaine automatically puts the brain into a state where people review traumatic memories from a position of emotional neutrality. They reconsolidate these memories without the overwhelming emotional charge.
  • Brain Age Reversal: Perhaps most remarkably, AI analysis of brain scans showed participants’ brains appeared 1.5 years younger one month after treatment. We’re talking about neurological age reversal from a single dose.

The Addiction Breakthrough

The anti-addiction effects are perhaps the most dramatic. Veterans in the study weren’t seeking addiction treatment, yet nearly all reported their alcohol consumption dropped to almost zero. They didn’t expect this outcome, it was an “off-target” effect that speaks to ibogaine’s broad reset of the reward system.

This mirrors the original discovery story: fifty years ago, a heroin addict in Amsterdam tried some pills, and the next day his addiction and withdrawal symptoms were completely gone. That launched decades of underground research.

The Safety Question

Yes, ibogaine has cardiac risks. It can cause dangerous heart rhythm abnormalities. But here’s the crucial context: many FDA-approved drugs carry similar or greater cardiac risks. The difference is stigma around mental illness versus “real” medical conditions.

We use a cardiac drug called Tikosyn that has a 1 in 100 risk of life-threatening arrhythmias to treat atrial fibrillation. We justify this risk because untreated A-fib can cause fatal strokes. Yet we resist studying ibogaine for severe PTSD or addiction, conditions with extremely high mortality rates, because of similar cardiac risks.

The solution isn’t to ignore the risk but to manage it properly. Prophylactic intravenous magnesium appears to prevent these cardiac complications entirely. Dr. Williams reports that clinics using this protocol haven’t had cardiac events.

Beyond Current Applications

The implications extend far beyond PTSD and addiction. With 75% of Americans overweight and 14% of the global population addicted to food (the same rate as alcohol addiction), could ibogaine address food addiction? The dopamine system reset that eliminates drug cravings might work for sugar and processed food cravings too.

We’re also seeing signals for traumatic brain injury recovery, cognitive enhancement, and even potential applications in neurodegenerative diseases through its effects on neuroplasticity.

The Path Forward

We’re entering “Psychiatry 3.0” moving from talk therapy (1.0) and crude pharmacology (2.0) to circuit-based interventions that can rapidly reset dysfunctional brain networks.

Dr. Williams expects FDA approval for human trials soon, with Texas allocating $50 million for ibogaine research. Within 5-10 years, we might have safe, monitored protocols available in the US.

But we also need to combine these breakthroughs with metabolic psychiatry, addressing the inflammation, nutrient deficiencies, and metabolic dysfunction that underlie many mental health issues. Ibogaine might provide the neurological reset that makes other therapeutic interventions more effective.

The Bigger Picture

We’re at an inflection point in medicine. For too long, we’ve treated mental illness as somehow less “real” than physical illness, stigmatizing conditions that are literally structural and functional problems in the brain.

Imagine if someone was limping from a torn meniscus and we said, “You’re just weak, think positive thoughts.” That’s essentially how we’ve approached depression, PTSD, and addiction. But these are measurable, physical brain dysfunctions that we can now see on scans and treat with precision.

The ibogaine revolution represents hope for millions suffering from treatment-resistant mental illness. It’s not just about incremental improvement, it’s about fundamental brain repair and reset.

As we move forward, we need courage from researchers like Dr. Williams, support for rigorous clinical trials, and a willingness to challenge our assumptions about what’s possible in mental healthcare.

The future of psychiatry isn’t about managing symptoms with daily pills that barely work. It’s about profound healing through compounds that have co-evolved with human consciousness for millennia.

This article is based on my recent podcast interview with Dr. Nolan Williams from Stanford University. For complete scientific references and the full conversation, listen to The Doctor Hyman Show: https://youtu.be/qwFhTkcUXog?si=5bPIRooZ89uWiy16

https://www.linkedin.com/in/drhyman

TOPLEY’S TOP 10 September 04, 2025

1. NVDA -8.5% from Highs…Closes Below 50 Day Moving Average

StockCharts


2. Average Stock Return of Names Added to S&P 500 in Last 5 Years-Nasdaq Dorsey Wright

NASDAQ DORSEY WRIGHT


3. 30-Year Government Bonds Globally Higher Rates

Reuters


4. Gold Value vs. History

Marketwatch By Steve Goldstein

MarketWatch


5. Silver Prices vs. Mining

Otavio (Tavi) Costa


6. S&P vs. Commodity Index 25-Year Valuation Spread


7. Average Price of Used Tesla vs. Used Car Market

@Charlie Bilello 3 years ago, the average price of a used Tesla was over $36k higher than the average price of all used cars. Today, the average price of a used Tesla is lower than than the average price of all used cars.


8. Breakdown of Gas Prices

EIA


9. History of Marriage/Homeowner Ages

Peter Mallouk


10. The hustle loop-Seth’s Blog

When we fall behind, it’s tempting to hustle to catch up.

When the competition heats up, it’s imperative we hustle to get ahead.

Hustle is a particular kind of shortcut. Hustle is pushing the boundaries of cultural expectation, creating pressure and discomfort to make a sale. Hustle pushes us to cut corners, cut the line and cut down trust.

And it quickly becomes the new normal. Hustling is a race to the bottom, and our competitors lean and hustle in response… which means that we’re now under pressure to hustle more than we think is appropriate, driven by the same forces that led us to hustle in the first place.

The alternative is to lean into better. To find the space and the guts to do breakthrough work, work that others are afraid to do. Instead of causing discomfort and cutting, we’re building something worth following and talking about.

Of course it’s not easy, that’s why it works.

https://seths.blog

TOPLEY’S TOP 10 September 03, 2025

1.International Stock Breakout?

https://www.topdowncharts.com


2.US M2 Money Supply No Slowdown in Growth

Zach Goldberg Jefferies …. The US M2 money supply surged +4.8% YoY in July, to a record $22.12 trillion. This also marks the 21st consecutive monthly increase.

3.Micro-Cap Stocks Approaching All-Time Highs.

https://www.google.com/finance/quote/IWC:NYSEARCA


4.U.S. Dollar Chart of Year 2025—Hits Support Going Back to Early 2024

www.stockcharts.com


5.Stock Buybacks Pass $1 Trillion in 2025

https://www.marketwatch.com/story/stock-buybacks-just-passed-the-1-trillion-mark-at-the-quickest-rate-ever-f653827f?mod=home_lead


6.NATO Doubles Defense Spend.

https://www.capitalgroup.com/ria/insights/articles/why-security-durable-investment-theme.html?sfid=238885404&cid=81434152&et_cid=81434152&cgsrc=SFMC&alias=A-btn-LP-2-SecurityInvestment


7.Average American Family Health Insurance Premiums

https://bilello.blog/


8.AI Data Center CO2 Emissions More Than Aviation Industry-Prof G

https://profgmedia.com/


9.Revenue of Internet vs. Revenue of AI

In 2000, at the height of the dot-com bubble, revenue from internet subscriptions, e-commerce and PCs (which many bought to access the internet) was about $1.5 trillion (in 2024 dollars), which is orders of magnitude larger than the $20 to $30 billion in revenue likely to be generated this year for AI software. It is hard to imagine AI users paying more for services that can’t be used, in situations where the costs of mistakes are substantial.

Jeffrey Funk is a retired professor, tech consultant and the author of “Unicorns, Hype and Bubbles: A guide to spotting, avoiding, and exploiting investment bubbles in tech.”

Gary Smith is the author of more than 100 academic papers and 20 books, including “Standard Deviations: The truth about flawed statistics, AI and big data” (Duckworth, 2024) and (co-authored with Margaret Smith): “The Power of Modern Value Investing: Beyond Indexing, Algos and Alpha” (PalgraveMacmillan, 2024).

https://www.marketwatch.com/story/ai-stocks-are-in-a-bubble-why-are-so-many-investors-refusing-to-believe-it-cf6e1624?mod=home_lead


10.Real Influence.

Andy Lopata-Psychology Today

https://www.psychologytoday.com/us/blog/connected-leadership/202508/the-real-reason-people-will-listen-to-you

TOPLEY’S TOP 10 September 02, 2025

1. 70% of S&P 500 Trading Above 200 Day Moving Average.

That shouldn’t be a surprise when for the first time this year, more than 70% of the S&P 500 stock are above the 200-day.

Source: Willie Delwiche


2. S&P Forward P/E Ratios by Sector.

https://www.barrons.com/articles/stock-market-outlook-f25a09ec?mod=past_editions


3. 2019-2025….9 of 11 Sector Market Caps Shrunk.

https://www.nasdaq.com/solutions/global-indexes/nasdaq-dorsey-wright/research-analysis-platform


4. Putting NVDA Valuation in Perspective. 

Bespoke Investment Group If you thought comparing NVIDIA to entire countries was wild, our next chart shows just how far ahead it is of some of America’s most iconic companies. With a market cap north of $4 trillion, NVIDIA is worth 6 Walmarts (WMT), 11 Costcos (COST), 20 McDonald’s (MCD), or 25 Citigroups (C). Taking it further, it could swallow 38 Nikes (NKE), 45 Starbucks (SBUX), or 50 Dells (DELL). At the extreme end, NVIDIA’s value equals about 60 UPS (UPS), 78 Chipotles (CMG), 94 Fords (F), 102 Targets (TGT), or 103 eBays (EBAY). Put simply, NVIDIA’s market cap isn’t just massive, it’s in a league of its own, making even household corporate giants look like small caps by comparison.

Bespoke https://www.bespokepremium.com


5. Foreign Central Banks Hold More Gold Than U.S. Treasuries.

Central banks vs. gold. “Foreign central banks now officially hold more gold than US Treasuries — for the first time since 1996.”

@tavicosta


6. Volatility has been Crushed, with the $VIX Showing its Biggest 20-week Decline in History.


7. IWM Small Cap Best August in 100 Years.

https://x.com/MikeZaccardi


8. Real Estate Still Ranks High as Investment for 21-44 Year Old

While crypto has been popular for wealthy Americans, real estate continued to hold greater appeal. And it’s the smart real estate entrepreneurs that know where to disrupt.

Take the $1.3T vacation home market1, where houses have traditionally been too expensive or too much hassle. After selling his own company to Zillow for $120M, Austin Allison applied his proptech expertise to create Pacaso: a co-ownership platform for luxury vacation homes.

Since inception, the company has generated $1B+ worth of luxury home transactions and service fees across 2,000+ owners. Well-known VCs have already invested — and until 9/18, Pacaso is offering everyday investors the chance to share in their growth at $2.90/share.2

http://www.chartr.com/


9. Scientists find musical link to boosting brain function for life

By CHRIS MELORE, US ASSISTANT SCIENCE EDITOR

Learning to play a musical instrument can protect your brain from aging, building up a defense against cognitive decline that lasts a lifetime.

Researchers from Canada and China discovered older adults who had spent years playing music were better at understanding speech in noisy environments, like a crowded room, compared to those who didn’t play music.

Their brains worked more like younger people’s brains, needing less energy to focus than older non-musicians’ brains had to use to make up for age-related mental declines.

Playing music was found to build up a person’s ‘cognitive reserve,’ which is like a backup system in the brain.

This reserve helps the brain stay efficient and work more like a younger brain, even as someone grows older.

Years of music training strengthened connections between brain areas that handle hearing, movement, and speech, making it easier to process sounds in tough situations, like when it’s hard to single out one voice in a crowd. 

Researchers said their findings debunked the idea that older brains always need to work harder to compensate for aging.

Instead, regularly practicing an instrument for about 12 hours a week, regardless of how well you play, can build up a ‘reserve’ that keeps the brain from having the think too hard unnecessarily. 

https://www.dailymail.co.uk/sciencetech/article-15054439/simple-hobby-boosts-brain-function-life.html


10. Tiny Thoughts Shane Parish

Luck writes the first chapter, but your actions write the rest. 

** 

Something I try to teach the kids is the concept of ‘one more.’ 

One more rep. 
One more step. 
One more minute. 
One more revision. 
One more practice test. 

It’s so easy to stop, but most of the value comes from one more. 

*** 

School often teaches that correct answers are obvious. Reality is the opposite. 

We drill kids on facts that seem obvious once known, never mentioning that almost all of them were buried behind a door of ‘that doesn’t make sense.’ Gravity baffled us for millennia. We didn’t think hand washing mattered, even the idea of germs causing sickness sounded insane. 

Every breakthrough started as heresy. But we teach kids to flee from the very feeling that precedes discovery.

https://fs.blog/about/

TOPLEY’S TOP 10 August 27, 2025

1. Earnings Still Trending Higher

EPS outlook. “S&P 500 forward earnings per share rose to yet another new record high during the week of August 21 as industry analysts raised their 2025 and 2026 earnings estimates.”

Ed Yardeni – Yardeni Research


2. NVDA Earnings Post Close Wed….History of Post-Earnings

Dorseywright


3. Chat GPT Threat to Google Search?  Google New Highs

StockCharts


4. Google Outperforming MSFT Since Chat GPT Launch

Bespoke


5. In Small Caps Last 5 Years….Value has Been Outperforming Growth

Y Charts


6. Nvidia’s new ‘robot brain’ goes on sale for $3,499 as company targets robotics for growth-CNBC

Kif Leswing@kifleswing

Key Points

  • Nvidia announced on Monday that its latest robotics chip module, the Jetson AGX Thor, is now on sale for $3,499 as a developer kit.
  • The company calls the chip a “robot brain.” The first kits ship next month, Nvidia said last week, and the chips will allow customers to create robots.
  • Nvidia CEO Jensen Huang has said robotics is the company’s largest growth opportunity outside of artificial intelligence.

Nvidia announced Monday that its latest robotics chip module, the Jetson AGX Thor, is now on sale for $3,499 as a developer kit.

The company calls the chip a “robot brain.” The first kits ship next month, Nvidia said last week, and the chips will allow customers to create robots.

After a company uses the developer kit to prototype their robot, Nvidia will sell Thor T5000 modules that can be installed in production-ready robots. If a company needs more than 1,000 Thor chips, Nvidia will charge $2,999 per module.

CEO Jensen Huang has said robotics is the company’s largest growth opportunity outside of artificial intelligence, which has led to Nvidia’s overall sales more than tripling in the past two years.

“We do not build robots, we do not build cars, but we enable the whole industry with our infrastructure computers and the associated software,” said Deepu Talla, Nvidia’s vice president of robotics and edge AI, on a call with

https://www.cnbc.com/2025/08/25/nvidias-thor-t5000-robot-brain-chip.html\


7. COIN -30% from Highs

StockCharts


8. Labor Day Steaks will be Expensive

Barchart


9. San Fran Homeless Citations up 25X

WSJ Last year, the U.S. Supreme Court granted cities more power to penalize people for sleeping outside, handing city leaders a new tool with which to clear homeless people from the streets.

WSJ


10. Appeal to System 1 thinking -INC

Daniel Kahneman, the Nobel Prize-winning psychologist, said the human brain makes decisions based on two ways of thinking, or what he called systems. System 1 is your brain’s autopilot. It assesses a situation quickly without a sense of voluntary control. System 2 takes its time. It’s more logical and deliberate. When people hear a message for the first time, System 1 kicks into action. It decides almost instantly, “Is this useful to me?” If the answer is yes, it pays attention. If the answer is no, it tunes out. 

One of the brain’s primary functions is to conserve energy, so it’s constantly scanning its environment to pay attention to those things that matter and ignore the rest. When the brain locks on to something important, System 2 takes over. It will look for logical arguments supported with facts, figures, data, and evidence. System 1, however, acts as the gatekeeper. 

The importance of audience-centric communication 

In audience-centric communication, it’s critical to make the benefit clear in the first 30 seconds of a presentation. If your listeners have to work too hard to decipher what you say and how it applies to them, you’ve lost their attention. It’s important to make your topic worth their mental energy. 

One easy way to get your audience locked in is to start with the benefit, and then back into the topic. For example, when I began a keynote presentation for an AI summit at MIT, I opened with this line: “Full disclosure. I am not here to tell you how to do your job.” Since the audience was made up of researchers who are deeply involved in the field of AI, it was important that I acknowledge the obvious—I’m not an AI scientist.

In my second sentence, just 14 seconds after I took the stage, I said, “I am here to elevate the job you do by giving you specific, tactical tools and techniques that will help you sharpen the most critical leadership skill that you can build today.”   

I could have used the first 30 seconds or so to talk about my books, credentials, or experience, but none of those things would have given the audience a reason to care. Those details support my ideas and lend credibility to my argument, but they won’t make it through the System 1 gatekeeper. Play to the gatekeeper first. Once you get your audience to lean in, you’ll have their attention, and they’ll be eager to hear what you say next. 

The opinions expressed here by Inc.com columnists are their own, not those of Inc.com.

https://www.inc.com/carmine-gallo/a-timeless-communication-tactic-steve-jobs-used-to-hook-any-audience/91228522?utm_source=newsletters&utm_medium=email&utm_campaign=INC+-+This+Morning+Newsletter.2025-08-25+-+8791&leadId=1548979&mkt_tok=NjEwLUxFRS04NzIAAAGcf_yNtpBSaqm54Ge5aywCtPRS9tbC1zU-pCHphDVE9A6g-wicMilEBlMSbr0BWJyW6WyMMnajCE3PHVwUQITOLw6nsbZfjfmXmjUuSJ2upUg